hrp0082fc5.1 | Neuroendocrinology | ESPE2014

Derivation of GnRH Neuron-Like Cells from Human Embryonic Stem Cell-Derived Neural Crest Progenitors

Noisa Parinya , Chokechuwattanalert Hataiwan , Lund Carina , Tuuri Timo , Raivio Taneli

Background: Neural crest (NC) cells emerge at the interface between neural and non-neural ectoderm, and migrate extensively to form a variety of NC derivatives such as peripheral neurons, glia, melanocytes, endocrine cells, and mesenchymal precursor cells. NC cells possess various unique properties and are capable of undergoing cell fate decisions across multiple tissues and germ layers. In zebrafish and mouse, GnRH neurons are reported to arise also from NC.<p class="abst...